This is a list of the Canadian RPM magazine number one singles of 2000. The final RPM chart was issued on 6 November 2000 after which the magazine ceased publication. The songs after that date are from Billboard magazine's Hits of the World Section, originally published by SoundScan in Canada.
identifies Canadian musical acts.
| Volume:Issue | Issue Date(s) | Weeks on Top | Song | Artist |
| 70:8-9 | 13 December - 3 January 2000 ÷ | 2 ÷ | "Blue" | Eiffel 65 |
| 70:10-11 | 10 January - 17 January | 2 | "I Knew I Loved You" | Savage Garden |
| 70:12 | 24 January | 1 | "What a Girl Wants" | Christina Aguilera |
| 70:13-14 | 31 January - 7 February | 2 | "I Knew I Loved You" | Savage Garden |
| 70:15-16 | 14 February - 21 February | 2 | "What a Girl Wants" | Christina Aguilera |
| 70:17-18 | 28 February - 6 March | 2 | "Show Me the Meaning of Being Lonely" | Backstreet Boys |
| 70:19 | 13 March | 1 | "Faded" | soulDecision |
| 70:20 | 20 March | 1 | "Bye Bye Bye" | 'N Sync |
| 70:21-23 | 27 March - 10 April | 3 | "Never Let You Go" | Third Eye Blind |
| 70:23 | 17 April | 1 | "Maria Maria" | Santana |
| 70:24-25, 71:1-3 | 24 April - 22 May | 5 | "It Feels So Good" | Sonique |
| 71:4-9 | 29 May - 3 July | 6 | "Oops!… I Did It Again" | Britney Spears |
| 71:10-12 | 10 July - 24 July | 3 | "It's Gonna Be Me" | 'N Sync |
| 71:13-14 | 31 July - 7 August | 2 | "Bent" | Matchbox Twenty |
| 71:15 | 14 August | 1 | "Bang Bang Boom" | The Moffatts |
| 71:16-18 | 14 August - 4 September | 3 | "Bent" | Matchbox Twenty |
| 71:19-26 | 11 September - 6 November ‡ | 9 ‡ | "Music" | Madonna |
| N/A | 11 November - 16 December | 5 | "Shape of My Heart" | Backstreet Boys |
| N/A | 23 December - 30 December | 2 | "Liquid Dreams" | O-Town |
÷ - Due to a two week break in RPM publication over the 1999/2000 Christmas/New Year time, the intervening weeks are inferred.
‡ - No RPM issue was published for 23 October.
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